vertical fist

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Have just been reading bits of Jack Dempsey's Championship fighting book online.He talks about using a vertical fist and aiming with the knuckle of the ring finger.So when you hit a target what knuckles do you aim with and what knuckles make contact?do you try to land with the three knuckles etc?or do you use the whole surface of the vertical fist e.g the knucks and fingers?
also do you use the wrist motion as in the one inch punch demo when doing a normal straight punch?or do you think this is unsafe because it puts too much pressure on the little finger knuckle which is weak?