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Thread: fearable bird flu

  1. #16
    Join Date
    Dec 1969
    Fremont, CA, U.S.A.


    The raging bird flu in China is a good reminder the US isn't prepared for a pandemic
    The virus has a fatality rate of up to 40 percent.
    Updated by Julia Belluz@juliaoftoronto Mar 3, 2017, 12:19pm EST

    H7N9 typically surfaces at live poultry markets in China. Forty percent of those with confirmed infections have died — including at least 87 people this year alone. Karl Johaentges / LOOK-foto.

    A strain of deadly bird flu that has a high risk of becoming a pandemic is surging in China, and experts are warning that the US isn’t making the necessary preparations.

    According to an assessment from the World Health Organization this week, China had 460 lab-confirmed human cases of the H7N9 bird flu virus since last October — the most of any flu season since the virus was first reported in humans in 2013.

    This makes the current outbreak the largest on record for H7N9, a virus that typically circulates around poultry markets and can cause pneumonia or death when it spreads to people. Forty percent of those with confirmed H7N9 infections have died — including at least 87 people this year alone. That’s a very deadly pathogen.

    The risk of the current outbreak causing a global epidemic is low right now, the WHO said. Almost all of the current infections were caught directly from birds and there’s no evidence yet of ongoing human-to-human transmission. But whenever bird flu spreads to people, there’s always the worry that it will mutate to become more contagious.

    Ronald Klain ✔ @RonaldKlain
    WARNING: America isn't ready & the Trump Admin--understaffed, inexperienced, isolationist--DEFINITELY isn't ready:
    1:08 PM - 28 Feb 2017

    Photo published for Human cases of H7N9 bird flu are surging, officials say
    Human cases of H7N9 bird flu are surging, officials say
    The H7N9 bird flu virus, which has sickened and killed several hundred people in China, had seemed to be diminishing as a threat.
    731 731 Retweets 650 650 likes
    Most people at risk of H7N9 virus right now are in China, particularly those who work in the poultry sector. Vietnam should also be on guard; reports suggest the virus has surfaced there as well.

    But if this H7N9 outbreak were to spread further, experts say we’re not ready.

    “America has long been unprepared for a dangerous pandemic, but the risks are especially high under President Trump,” the former Ebola czar Ron Klain told Vox.

    Trump hasn’t yet named nominees for a new head to the Centers of Disease Control and Prevention, the agency that would lead a pandemic response. He also hasn’t nominated anyone to head Assistant Secretary for Preparedness and Response, or USAID — two other key agencies in a pandemic.

    With the repeal of the Affordable Care Act looming, Trump is poised to gut a key public health fund that accounts for 12 percent of the CDC’s budget, and he’s reinstated the global gag rule, which depletes global health funding. “His proposed cuts in foreign aid,” Klain added, “will devastate work to detect and combat disease outbreaks abroad — the very best way to prevent those diseases from coming to America.”

    If it’s not a bird flu outbreak, it’ll be some other health threat. The pace at which pathogens are flying around the globe and threatening pandemics is only accelerating. Over the past decade, the WHO has declared four global health emergencies. Two of them happened during President Obama’s tenure (Ebola and Zika). There’s slim chance Trump will finish a four-year term without facing an outbreak of some kind.

    As for H7N9, it’s very possible it could spread to birds and people in other countries, said Dr. Tim Uyeki, a medical epidemiologist in CDC’s influenza division.

    “Among the viruses we’ve assessed... H7N9 is the most concerning. It’s at the top of the list,” Uyeki said. “We don’t know when the next pandemic is going to start, where it’s going to start. But at this time the biggest concern is the H7N9 virus.”

    Treating the current cases is also proving to be a challenge since some seem to carry genetic markers associated with drug resistance to antiviral treatments for the disease, like Tamiflu. A new assessment from the CDC also shows the virus has also split into a new lineage — which is a problem because the vaccine development for H7N9 was based on an older lineage of the virus. So we don’t have any vaccine candidates in the pipeline to fully address the current outbreak.
    It's important to understand that H7N9 is different than H5N1. There are about 40 different strains of Avian Flu.
    Gene Ching
    Author of Shaolin Trips
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  2. #17
    Join Date
    Dec 1969
    Fremont, CA, U.S.A.

    Here it comes...

    BY REUTERS ON 3/5/17 AT 5:35 PM
    First Study Of Human Transmission Of New Bird Flu Raises Worries


    A strain of bird flu has been detected in a commercial chicken breeder flock in Tennessee's Lincoln County and the 73,500 birds will be culled to prevent the virus from entering the food system, U.S. and state agriculture officials said on Sunday.

    The U.S. Department of Agriculture said this represented the first confirmed case of highly pathogenic H7 avian influenza (HPAI) in commercial poultry in the United States this year.

    The facility has been placed under quarantine, along with approximately 30 other poultry farms within a 6.2-mile (10 km) radius of the site, the Tennessee state government said. Other flocks in the quarantined area are being tested for the virus, it added.

    A Centers for Disease Control scientist measures the amount of H7N9 avian flu virus which was grown and harvested in an unnamed CDC laboratory in 2013.

    In 2014 and 2015, the United States killed nearly 50 million birds, mostly egg-laying hens, during a bout of HPAI. The losses pushed U.S. egg prices to record highs and prompted trading partners to ban imports of U.S. poultry.

    No humans were affected in that outbreak. The risk of human infection in poultry outbreaks is low, although in China people have died this winter amid an outbreak of the H7N9 virus in birds.

    HPAI bird flu was found in a commercial turkey flock in Indiana in January 2016 but there have been no other cases in commercial flocks until now.

    The breeders at the Tennessee facility were for the broiler flock, USDA spokeswoman Donna Karlsons said in an email.

    In January, the USDA detected bird flu in a wild duck in Montana that appeared to match one of the strains found during the 2014 and 2015 outbreak.

    In recent months, different strains of bird flu have been confirmed across Asia and in Europe. Authorities have culled millions of birds in affected areas to control the outbreaks.

    France, which has the largest poultry flock in the European Union, has reported outbreaks of the highly contagious H5N8 bird flu virus. In South Korea, the rapid spread of the H5N6 strain of the virus has led to the country's worst-ever outbreak of bird flu.
    TN has 30 poultry farms within a 6.2-mile radius of the site. That seems dense, but perhaps there are as many poultry farms in any such region. Americans eat a lot of nuggets.
    Gene Ching
    Author of Shaolin Trips
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  3. #18
    Join Date
    Feb 2003
    Under the old oak tree

    Chinese herbal remedy Lianhuaqingwen inhibits influenza virus in vitro!po=19.5652

    Easily formulated but contains ephedra, which is banned in the US. Acupuncturists and Herbalists need to unite to educate the FDA on the truth regarding ephedra. In the TCM application of this medicinal, it has a high margin of safety and an incredible efficacy... but that's another discussion for another time.


    Lianhuaqingwen Capsule (LH-C) is a traditional Chinese medicine (TCM) formula used to treat respiratory tract infectious diseases in Chinese. The aim of this study was to determine the antiviral activity of LH-C and its immunomodulatory effects on viral infection.


    The in vitro cytotoxicity and antiviral activity of LH-C was determined by MTT and Plaque reduction assays. Time course study under single-cycle virus growth conditions were used to determine which stage of viral replication was blocked. The effect of LH-C on the nuclear export of the viral nucleoprotein was examined using an indirect immunofluorescence assay. The regulation to different signaling transduction events and cytokine/chemokine expression of LH-C was evaluated using Western blotting and real-time RT-PCR. After virus inoculation, BALB/c mice were administered with LH-C of different concentrations for 5 days. Body-weight, viral titers and lung pathology of the mice were measured, the level of inflammatory cytokines were also examined using real-time RT-PCR.


    LH-C inhibited the proliferation of influenza viruses of various strain in vitro, with the 50% inhibitory concentration (IC50) ranging from 0.35 to 2 mg/mL. LH-C blocked the early stages (0–2 h) of virus infection, it also suppressed virus-induced NF-kB activation and alleviated virus-induced gene expression of IL-6, IL-8, TNF-a, IP-10, and MCP-1 in a dose-dependent manner. LH-C treatment efficiently impaired the nuclear export of the viral RNP. A decrease of the viral titers in the lungs of mice were observed in groups administered with LH-C. The level of inflammatory cytokines were also decreased in the early stages of infection.


    LH-C, as a TCM prescription, exerts broad-spectrum effects on a series of influenza viruses, including the newly emerged H7N9, and particularly regulates the immune response of virus infection. Thus, LH-C might be a promising option for treating influenza virus infection.

  4. #19
    Join Date
    Dec 1969
    Fremont, CA, U.S.A.


    More dead. Less panic. Go figure.

    161 people have been killed by bird flu this winter in China's worst outbreak since 2009
    BY ALEX LINDER IN NEWS ON MAR 14, 2017 12:35 AM

    This year's bird flu season continues to set records in China with the virus infecting another 160 people and killing 61 in the month of February.
    Since last October, 161 people have been killed by the H7N9 virus in the most deadly avian flu outbreak the country has seen since at least 2009, the Chinese government said on Monday.
    Fortunately, the worst is likely behind us. Fatalities dropped in February from a high of 79 in January. Infections tend to fall off at the end of winter.

    Following a bird flu outbreak in 2013 that caused widespread panic, killing 36 people and resulting in more than $6 billion in economic losses for China's agricultural sector, China began to institute measures to contain and prevent the disease.
    This winter, those policies led to poultry markets around the country being shut down and some 175,000 birds being culled as Chinese authorities have become increasingly worried about the spread of the deadly virus.
    Gene Ching
    Author of Shaolin Trips
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  5. #20
    Join Date
    Feb 2003
    Under the old oak tree

    Don't start licking those frogs yet

    Not TCM related per se but along the lines of ethomedicine origins of emerging pharmaceutical interventions... h.ox

    Frog Skin Mucus May Help Kill Strains Of Flu Virus
    19 April 2017, 7:13 am EDT By Allan Adamson Tech Times

    Name:  frog.jpg
Views: 245
Size:  92.8 KB

    The slime that coats the skin of a species of colorful frogs found in southern India may help kill strains of the flu virus.

    In a new study involving mice, researchers found that certain peptides present in the skin mucus of the Hydrophylax bahuvistara frogs can kill the H1 variety of influenza viruses.
    What Are Peptides?

    Peptides are short chains of amino acids that are known as the building blocks of protein. The skin of frogs secretes peptides that can kill viruses and bacteria.

    Findings of a new research published in the journal Immunity on April 18 suggest that these peptides could be a potential source of new antiviral and antimicrobial treatments.

    Such treatments can help when vaccines are not available to deal with new strains of pandemic flu or once currently known flu strains develop resistance to available drugs. Flu comes in several varieties and may evolve into new forms, which is why researchers need to develop new vaccines for a specific type of the virus every flu season.

    Frogs As Source Of Defense Peptides

    All animals produce at least a few antimicrobial host defense peptides since these are involved in the workings of their immune systems. Frogs, however, are of interest to researchers as a source of these peptides because it is relatively easy to isolate peptides that are found in their mucus.

    All the researchers need to do is give the amphibians an electric shock. They can also rub a powder on the animals so they would secrete their defense peptides.


    Jacob and his colleagues looked at 32 frog defense peptides for use against a flu strain and found that four of these had flu-busting abilities.

    Unfortunately, when they exposed isolated human red blood cells to these peptides, they found that three of the four peptides were toxic.

    Urumin, one of the peptides present in the frog's mucus, appeared harmless to human cells but was found lethal to a range of flu viruses.
    How Urumin Works Against Flu Viruses

    Urumin works by targeting the viral surface protein hemagluttinin, the H in H1N1.

    "The virus needs this hemagglutinin to get inside our cells," said study researcher Joshy Jacob of Emory University. "What this peptide does is it binds to the hemagglutinin and destabilizes the virus. And then it kills the virus."

    In experiments involving mice, urumin, was found to provide protection to unvaccinated mice. The peptide binds to a protein that is identical across many strains of influenza. Researchers found that the peptide can neutralize dozens of flu strains ranging from the 1934 archival viruses to those that sprung in modern times.
    Urumin As Potential Antiviral Treatment For Flu

    Urumin appears to have limitation. The peptide protected mice against a lethal dose of H1 flu strain but it was not found effective against the H3N2. Researchers though remain optimistic of its potentials as a treatment for flu.

    "Urumin represents a unique class of anti-influenza virucide that specifically targets the hemagglutinin stalk region, similar to targeting of antibodies induced by universal influenza vaccines," Jacob and colleagues wrote in their study.

    "Urumin therefore has the potential to contribute to first-line anti-viral treatments during influenza outbreaks."
    - See more at:

  6. #21
    Join Date
    Dec 1969
    Fremont, CA, U.S.A.

    ttt 4 2019!

    China reports new bird flu outbreak in Yunnan province

    Reuters 2m

    BEIJING (Reuters) - China reported a new H5N6 bird flu outbreak in the southwestern province of Yunnan, the agriculture ministry said on Friday.

    The new case, found on a poultry farm with 2,861 birds in Lijiang city in Yunnan, infected and killed 463 of the animals, China's Ministry of Agriculture and Rural Affairs said in a statement published on its website.

    Local authorities have culled 55,917 birds following the outbreak, according to the statement.

    (Reporting by Hallie Gu and Ryan Woo; Editing by Tom Hogue)
    poultry pestilence
    Gene Ching
    Author of Shaolin Trips
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  7. #22
    Join Date
    Dec 1969
    Fremont, CA, U.S.A.

    Oh ****

    Published: February 4, 2020 3:19 PM UTC
    Bird Flu: China’s Ticking Time Bomb of Infectious Disease
    As the world grapples with the Wuhan coronavirus outbreak, a new disease emerges: a highly-fatal bird-flu known as H5N1.
    Author: William Ebbs @ebbs_william

    As China's ascendancy to world power continues, infectious diseases could become the norm. | Image: REUTERS / Bobby Yip / File Photo

    A highly pathogenic strain of bird flu, H5N1, has caused an outbreak in China’s Hunan province, near ground zero of the deadly coronavirus.

    The disease doesn’t easily infect humans but when it does, it carries a staggering mortality rate of 60% according to the WHO.

    China is a hotbed of emerging diseases. As the country rises to economic prominence, this puts the global economy at risk.

    For most people who live in first world countries, infectious diseases are not a big concern. We get a cocktail of vaccines as children and go on to live relatively healthy lives. The biggest things we have to worry about are the common flu, the common cold, and occasionally, strep throat. As China rises to global prominence, in a world that has grown increasingly interconnected, things may be changing.

    We could be reverting to a time when deadly diseases were a fact of life for everyone – in every country.

    As the global coronavirus outbreak grows to infect over 20,000 with 425 fatalities, China finds itself in the cross hairs of a new, dangerous outbreak: bird flu, an infection that can kill poultry and humans alike. While the disease, known as H5N1, hasn’t infected any humans yet, it’s revealing a disturbing pattern with global implications. New diseases are emerging at an alarming rate, and this puts the whole world at risk.

    The Coronavirus Is Still At Large

    According to the latest data, Wuhan coronavirus has grown to infect 20,680 people – the majority in Hubei province, China. The disease has spread to 27 countries and 427 people have died.

    In response, U.S authorities have taken drastic actions to limit contact with China. The State Department has issued a travel warning, airlines are canceling flights and American companies with Chinese operations are shuttering operations in the country.


    Authorities should have the ability to get the coronavirus under control but what will they do when the next massive outbreak crops up? Can the global economy withstand these repeated shocks?

    Another Outbreak: Bird Flu

    According to China’s Ministry of Agriculture and Rural Affairs, the nation is experiencing an outbreak of a highly pathogenic strain of bird flu called H5N1. The disease has already killed 4,500 chickens in Hunan province alone and the government has culled almost 18,000 chickens to prevent its spread.

    According to the United States Geological Survey, there’s no need to panic about the term “highly pathogenic” because it refers to the virus’s ability to kill chickens, not humans.

    They state the following:

    The designation of low or highly pathogenic avian influenza refers to the potential for these viruses to kill chickens. The designation of “low pathogenic” or “highly pathogenic” does not refer to how infectious the viruses may be to humans, other mammals, or other species of birds.
    The World Health Organization (WHO) paints a more disturbing picture of the disease.

    Human cases of H5N1 avian influenza occur occasionally, but it is difficult to transmit the infection from person to person. When people do become infected, the mortality rate is about 60%.
    They go on to elaborate

    Influenza viruses constantly undergo genetic changes. It would be a cause for concern, should the H5N1 virus become more easily transmissible among humans.

    A 60% mortality rate is staggering. To put this in perspective, note that coronavirus has a mortality rate of only 2.1% while SARS had a mortality rate of 9.6%. With a mortality rate of 60%, the bird flu is as deadly as Ebola. While it doesn’t currently spread well among humans, experts believe it can mutate into more virulent forms.
    This is a ticking time bomb.

    This article was edited by Sam Bourgi.

    William Ebbs @ebbs_william
    As a writer with over five years of experience, William Ebbs has contributed to CCN, The Motley Fool and other wonderful clients. He has earned millions of page views with his hard-hitting, opinionated work. He focuses on financial markets and business. When Will isn't writing, he enjoys strategy gaming, heated debates, and researching for his next article. William Ebbs is based in the United States of America and can be reached at
    Bird Flu
    Gene Ching
    Author of Shaolin Trips
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  8. #23
    Join Date
    Dec 1969
    Fremont, CA, U.S.A.

    Still a threat

    Bird flu: humans infected with H5N8 strain for first time in Russia
    Seven poultry workers found to be infected, but no evidence of transmission between humans

    Turkey hens in Germany. The H5N8 strain is deadly for birds, and this marks the first transmission of the strain from animals to humans. Photograph: Jens Buettner/EPA
    Molly Blackall
    Sat 20 Feb 2021 12.17 EST

    A H5N8 strain of bird flu has been detected in humans for the first time, among seven workers who were infected at a Russian poultry plant in December.

    There is no evidence of the strain being transmitted between humans, but Russia has reported the transmission to the World Health Organization.

    The workers now feel well, and “the situation did not develop further”, according to Dr Anna Popova, head of consumer health watchdog Rospotrebnadzor. She said the workers had been infected during an outbreak of the strain at the plant.

    Outbreaks of the strain have been reported in Russia, Europe, China, the Middle East and north Africa in recent months, but only in poultry.

    Other strains of bird flu, including H5N1, H7N9 and H9N2, have been transmitted to humans before.

    The H5N8 strain is deadly for birds, and this marks the first transmission of the strain from animals to humans. While Popova said the strain didn’t appear to be able to spread among humans, “only time will tell how soon future mutations will allow it to overcome this barrier”.

    The discovery of this strain “gives us all, the whole world, time to prepare for possible mutations and the possibility to react in a timely way and develop test systems and vaccines,” she said.

    The Vector Institute in Siberia said on Saturday that it would start developing human tests and a vaccine against H5N8, according to RIA news agency.

    Speaking on state TV, Popova said that Russia had reported the developments to the WHO several days ago, “just as we became absolutely certain of our results”.

    Most cases of human bird flu infections have been linked to direct contact with infected live or dead poultry, though properly cooked food is considered safe.

    The cases tend to be spread via migrating wild birds, leading producing countries to keep their poultry indoors or segregated from wildlife.

    Outbreaks of bird flu often lead poultry plants to kill their birds to prevent the virus spreading further, and often prompts other countries to impose trade restrictions. In the UK, five outbreaks of the H5N8 strain in Gloucestershire, Dorset, Devon, Cheshire and Kent were detected in November, leading officials to implement a prevention zone in England, Scotland and Wales.

    The Department for Environment, Food and Rural Affairs said that all birds in the affected areas had been culled “humanely” and control zones introduced.
    The future is in vaxxing...
    Gene Ching
    Author of Shaolin Trips
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  9. #24
    Join Date
    Dec 1969
    Fremont, CA, U.S.A.

    If it's not one plague...'s another.

    October 26, 2021
    12:50 AM PDT
    Last Updated 9 hours ago
    Rise in human bird flu cases in China shows risk of fast-changing variants: experts
    By Dominique Patton

    4 minute read

    A man provides water for chickens inside a greenhouse at a farm in Heihe, Heilongjiang province, China November 17, 2019. REUTERS/Stringer

    BEIJING, Oct 26 (Reuters) - A jump in the number of people in China infected with bird flu this year is raising concern among experts, who say a previously circulating strain appears to have changed and may be more infectious to people.

    China has reported 21 human infections with the H5N6 subtype of avian influenza in 2021 to the World Health Organization (WHO), compared with only five last year, it said.

    Though the numbers are much lower than the hundreds infected with H7N9 in 2017, the infections are serious, leaving many critically ill, and at least six dead.

    "The increase in human cases in China this year is of concern. It's a virus that causes high mortality," said Thijs Kuiken, professor of comparative pathology at Erasmus University Medical Centre in Rotterdam.

    Most of the cases had come into contact with poultry, and there are no confirmed cases of human-to-human transmission, said the WHO, which highlighted the rise in cases in a statement on Oct. 4.

    It said further investigation was "urgently" required to understand the risk and the increase in spill over to people.

    Since then, a 60-year-old woman in Hunan province was admitted to hospital in a critical condition with H5N6 influenza on Oct. 13, according to a Hong Kong government statement.

    While human H5N6 cases have been reported, no outbreaks of H5N6 have been reported in poultry in China since February 2020.

    China is the world's biggest poultry producer and top producer of ducks, which act as a reservoir for flu viruses.

    The Chinese Center for Disease Control and Prevention (CDC) could not be reached for comment on the rise in H5N6 human cases. However, a study published on its website last month said the "increasing genetic diversity and geographical distribution of H5N6 pose a serious threat to the poultry industry and human health".

    Avian influenza viruses constantly circulate in domestic and wild birds, but rarely infect people. However, the evolution of the viruses, which have increased as poultry populations grow, is a major concern because they could change into a virus that spreads easily between people and cause a pandemic.

    The largest number of H5N6 infections have been in southwestern Sichuan province, though cases have also been reported in neighbouring Chongqing and Guangxi, as well as Guangdong, Anhui and Hunan provinces.

    At least 10 were caused by viruses genetically very similar to the H5N8 virus that ravaged poultry farms across Europe last winter and also killed wild birds in China. That suggests the latest H5N6 infections in China may be a new variant.

    "It could be that this variant is a little more infectious (to people)...or there could be more of this virus in poultry at the moment and that's why more people are getting infected," said Kuiken.

    Four of the Sichuan cases raised poultry at home and had been in contact with dead birds, said a September report by China's CDC. Another had bought a duck from a live poultry market a week before developing symptoms.

    China vaccinates poultry against avian influenza but the vaccine used last year may only partially protect against emerging viruses, preventing large outbreaks but allowing the virus to keep circulating, said Filip Claes, Regional Laboratory Coordinator at the Emergency Centre for Transboundary Animal Diseases at the Food and Agriculture Organization.

    The Ministry of Agriculture and Rural Affairs did not respond to a request for comment.

    Backyard farms in China are common and many people still prefer to buy live chickens at markets.

    Guilin city in Guangxi region, which had two human cases in August, said last month it had suspended trading of live poultry in 13 urban markets and would abolish the trade within a year.

    Reporting by Dominique Patton; Editing by Michael Perry
    Gene Ching
    Author of Shaolin Trips
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