From, what we have seen of the various clips that show "effective" fighting VS multiples, it seems that the thing to do is to hit hard, in short combos, keep it standing, move from one to the other, to be aggressive and to dictate the pace ( or at least to not be dominated by their pace).
Psalms 144:1
Praise be my Lord my Rock,
He trains my hands for war, my fingers for battle !