Thank you all for your feedback, and sorry for the false alarm .
Reflecting on what you said, I understand that the hand will thicken way before there's any noticeable change in the bones/knuckles.
But doesn't it come at the expense of flexibility? I mean, in the long run, doesn't it impair the ability to use the hand (grab things, fold hand, tighten fist, etc.) if the hand is fatter but the bones relatively unchanged?
I am very curious and I tend to ask lots of (naive) questions, please do let me know if that's getting too annoying.
Thanks