A solid punch across the bridge of the nose is devastating.
It can literally suck the will to fight out of a man when he receives one of those.

for one thing, he can't see, his face feels like it is exploding with pain and lack of seeing is also disorienting.

It's a great place to punch someone if you wanna sit em down.

It's also a great reason for keeping your hands up and learn to slip, bob and weave instead of skip, jump and leave. lol